hormone-independent prostate cancer cell lines are resistant to antineoplastic drugs, this study sought to determine the usefulness of lithium chloride as an inhibitor of glycogen synthase kinase-3β to increase the cytotoxic effect of doxorubicin, etoposide or vinblastine antineoplastic drugs on du145 cells. combination effect was assessed by using low and ic50 doses of drugs + lithium chloride...

Hormone-independent prostate cancer cell lines are resistant to antineoplastic drugs, this study sought to determine the usefulness of lithium chloride as an inhibitor of glycogen synthase kinase-3β to increase the cytotoxic effect of doxorubicin, etoposide or vinblastine antineoplastic drugs on DU145 cells. Combination effect was assessed by using low and IC(50) doses of drugs + lithium chlori...

I The pharmacokinetics of the lithium ion administered as lithium orotate were studied in rats. Parallel studies were carried out with lithium carbonate and lithium chloride. 2 No differences in the uptake, distribution and excretion of the lithium ion were observed between lithium orotate, lithium carbonate and lithium chloride after single intraperitoneal, subcutaneous or intragastric injecti...

background: lithium has been the treatment of choice for bipolar disorder (bd) for many years. although erectile dysfunction is a known adverse effect of this drug, the mechanism of action by which lithium affects erectile function is still unknown. objective: the aim was to investigate the possible involvement of nitric oxide (no) in modulatory effect of lithium on penile erection (pe). we fur...

Distal nephron function of the rat during lithium chloride infusion. Chronic lithium (Li) administration in the rat leads to reduced renal concentration (TCH20) without alterations in renal dilution (CH), To examine the acute effects of lithium on TH2O and C1120, rats were infused with a solution composed of 1% sodium chloride and 1% lithium chloride or a 0.225% lithium chloride solution at rat...

vincristine (vcr) as a frequently used antimitotic agent which is commonly prescribed for wide spectrum of neoplasm, causes mixed sensorimotor neuropathy. several evidences show lithium could be a neuroprotective agent, therefore to assess whether a pretreatment and at subtherapeutic dose it could prevent the peripheral neuropathy produced by vcr, rats were treated with vcr 0.1mg/kg i.p. for 3 ...

Effect of high doses of lithium carbonate (40 rag/Kg.i.p. and p.o.) and lithium chloride (40 mg/Kg.i.p.) on renal and extra-renal functions were studied in normal male Charles Foster Strain of rats. Insignificant effect on urine output, creatinine clerance, sodium, potassium and lithium excretion was observed with these salts. Antidiuretic hormone levels were also not effected. However lithium ...

objective(s) it is believed that the mesenchymal stem cell (msc) differentiation and proliferation are the results of activation of wnt signaling pathway. on the other hand, lithium chloride is reported to be able to activate this pathway. the objective of this study was to investigate the effect of lithium on in vitro proliferation and bone differentiation of marrow-derived msc. materials and ...

one of the most important and serious disorders of gastrointestinal tract is acute pancreatitis which in severe form is associated with high mortality rate particularly in the presence of systemic inflammatory response and multiple organ failure. apoptosis linked to oxidative stress has been shown in the pancreas of the patients with acute pancreatitis. lithium, one of the most effective drugs ...